X4-Tropic Human Immunodeficiency Virus (HIV), IIIB Utilizes CXCR4 As Coreceptor Distinctly From R5 × 4-Tropic Viruses
نویسندگان
چکیده
منابع مشابه
Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2.
Human immunodeficiency virus type 1 (HIV-1) coreceptor usage and tropism can be modulated by the V3 loop sequence of the gp120 exterior envelope glycoprotein. For coreceptors, R5 viruses use CCR5, X4 viruses use CXCR4, and dual-tropic (R5X4) viruses use either CCR5 or CXCR4. To understand the requirements for dual tropism, we derived and analyzed a dual-tropic variant of an X4 virus. Changes in...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2013
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.12051